Hormones are chemical signals that help the body work well. They can also make certain cancers grow faster and spread farther. Hormonal therapy is used in cancer treatment to control cancer growth.

Hormonal therapy is often used to treat some advanced uterine cancer. Common therapies include:

  • Progestin—to counter the effects of estrogen
  • Tamoxifen—to block the effects of estrogen
  • Aromatase inhibitors—to block the production of estrogen
  • Luteinizing hormone-releasing hormone (LHRH) agonists—to lower estrogen levels by blocking the hormonal effects of the ovaries

Common side effects include:

  • Night sweats
  • Hot flashes
  • Vaginal dryness
  • Fluid retention
  • Increasing appetite
  • Joint and/or muscle pain
  • Increasing depression
  • Bone thinning, which can increase the risk of osteoporosis
  • Blood clots

Treatments can help manage side effects. Medicine, lifestyle changes, and alternative treatments have all shown to be helpful.

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